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Ebooks (Sách điện tử)

Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain

Authors : Harris, Noah J (2023)

PI3Kγ is a critical immune signaling enzym 31 e activated downstream of diverse cell 32 surface molecules, including Ras, PKCβ activated by the IgE receptor, and Gβγ 33 subunits released from activated GPCRs. PI3Kγ can form two distinct complexes, with 34 the p110γ catalytic subunit binding to either a p101 or p84 regulatory subunit, with these 35 complexes being differentially activated by upstream stimuli. Here using a combinati...

Journal article

Reconciling Conformational Heterogeneity and Substrate Recognition in Cytochrome P450

Authors : Dandekar, B. (2021)

Cytochrome P450, the ubiquitous metalloenzyme involved in detoxification of foreign components, has remained one of the most popular systems for substrate-recognition process. However, despite being known for its high substrate specificity, the mechanistic basis of substrate-binding by archetypal system cytochrome P450cam has remained at odds with the contrasting reports of multiple diverse crystallographic structures of its substrate-free form. Here we address this...