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  • OER000002540.pdf.jpg
  • Journal article

  • The C9Orf72 hexanucleotide repeat expansion aggregates by means of multimolecular G-quadruplex formation

    • Authors : Raguseo, Federica  (2023)

  • Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two neurodegenerative diseases genetically characterised by the expansion of the hexanucleotide repeat (GGGGCC)n. Here we investigated the formation of nucleic-acid secondary structures in the expansion repeats, and their role in generating aggregates that are characteristic of ALS/FDT. We observed significant aggregation of DNA (GGGGCC)n, which we ascribe to the formation of multimolecular G-quadruplexes&...