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  • OER000002663.pdf.jpg
  • Journal article

  • Chemical Proteomics Reveals Protein Tyrosination Extends Beyond the Alpha-Tubulins in Human Cells

    • Authors : Makarov, Dmytro  (2023)

  • Tubulin detyrosination-tyrosination cycle regulates the stability of microtubules. Thus far described on α-tubulins, the tyrosination level is maintained by a single tubulin-tyrosine ligase (TTL). However, the precise dynamics and tubulin isoforms which undergo (de)tyrosination in neurons are unknown. Here, we exploit the substrate promiscuity of the TTL to introduce an O-propargyl-L-tyrosine in neuroblastoma cells and neurons. Mass spectrometry-based chemical proteomics in neuroblas...
  • OER000002606.pdf.jpg
  • Journal article

  • Inhibition of SARS-CoV-2 3CLpro in vitro by chemically modified tyrosinase from Agaricus bisporus

    • Authors : Aguilera, David (2023)

  • Antiviral compounds are crucial to controlling the SARS-CoV-2 pandemic. Approved drugs have been tested for their efficacy against COVID-19, and new pharmaceuticals are being developed as a complementary tool to vaccines However, there are not any effective treatment against this disease yet. In this work, a cheap and fast purification method of natural tyrosinase from Agaricus bisporus fresh mushrooms was developed in order to evaluate the potential of&...
  • OER000002834.pdf.jpg
  • Journal article

  • Insights into design of mobility control for chemical enhanced oil recovery

    • Authors : Farajzadeh, R. (2019)

  • This study compares two methods of mobility-control design for chemical enhanced oil recovery processes. Method 1 matches the total relative fluid mobility upstream and downstream of the shock front. In method 2 the viscosity of the displacing agent is selected such that the total mobility at the shock water saturation is equal to or less than the minimum mobility across the saturation range. The two methods are based on ...