Browse

Author Profile

Browsing by Subject hóa học protein

Jump to: 0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
or enter first few letters:  
Showing results 1 to 2 of 2
  • OER000002916.pdf.jpg
  • Journal article

  • Dimerization mechanism and structural features of human LI-cadherin

    • Authors : Fleisher, Rachel C. (2021)

  • LI-cadherin is a member of the cadherin superfamily, which encompasses a group of Ca2+ dependent cell adhesion proteins. The expression of LI-cadherin is observed on various types of cells in the human body, such as normal small intestine and colon cells, and gastric cancer cells. Because its expression is not observed on normal gastric cells, LI-cadherin is a promising target for gastric cancer imaging. However, since...
  • OER000002625.pdf.jpg
  • Journal article

  • Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows

    • Authors : Appleby, Franco F; Abegg, Daniel (2023)

  • Macrocyclic peptides are attractive for chemoproteomic applications due to their modular synthesis and potential for high target selectivity. We describe a solid phase synthesis method for the efficient generation of libraries of small macrocycles that contain an electrophile and alkyne handle. The modular synthesis produces libraries that can be directly screened using simple SDS-PAGE readouts and then optimal lead molecules applied to proteomic ana...