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Showing results 1 to 5 of 5
  • OER000001806-1.pdf.jpg
  • Ebooks (Sách điện tử)

  • Advances in Fusion Energy Research - From Theory to Models, Algorithms, and Applications

    • Authors : Carpentieri, Bruno (2022)

  • Note 520 Fusion power may offer a long-term energy supply with an uninterrupted power delivery, a high power-generation density, and no greenhouse gas emissions, contributing to preventing the worst effects of climate change and making an enduring contribution to future energy supply. However, the intense conditions inside a fusion power plant (extreme temperatures and high magnetic fields necessary for nuclear fusion) call for addressing severa...
  • OER000002346.pdf.jpg
  • Journal Article

  • Bifunctional small molecules that induce nuclear localization and targeted transcriptional regulation

    • Authors : Gibson, William J. (2023)

  • The aberrant localization of proteins in cells is a key factor in the development of various diseases, including cancer and neurodegenerative disease. To better understand and potentially manipulate protein localization for therapeutic purposes, we engineered bifunctional compounds that bind to proteins in separate cellular compartments. We show these compounds induce nuclear import of cytosolic cargoes, using nuclear-localized BRD4 as a “carrier” for co-...
  • OER000002622.pdf.jpg
  • Journal article

  • Biochemical deconstruction and reconstruction of Nuclear Matrix reveals the layers of nuclear organization

    • Authors : Bihani, Ashish (2023)

  • Nuclear Matrix (NuMat) is the fraction of the eukaryotic nucleus insoluble to detergents and high-salt extractions that manifests as a pan-nuclear fiber-granule network. NuMat consists of ribonucleoprotein complexes, members of crucial nuclear functional modules, and DNA fragments. Although NuMat captures the organization of non-chromatin nuclear space, very little is known about component organization within NuMat. To understand the organization of NuMat...
  • OER000002383.pdf.jpg
  • Journal Article

  • Cross-linking mass spectrometric analysis of the endogenous TREX complex from S. cerevisiae

    • Authors : Kern, Carina (2023)

  • The conserved TREX complex has multiple functions in gene expression such as transcription elongation, 3’ end processing, mRNP assembly and nuclear mRNA export as well as the maintenance of genomic stability. In S. cerevisiae, TREX is composed of the pentameric THO complex, the DEAD-box RNA helicase Sub2, the nuclear mRNA export adaptor Yra1 and the SR-like proteins Gbp2 and Hrb1. Here, we present the structural analysis of the&#x...
  • OER000002337.pdf.jpg
  • Journal Article

  • The orphan nuclear receptor Nr2f6 impairs skeletal muscle oxidative capacity and regulates muscle mass in mice

    • Authors : malanmy, Nion (2023)

  • The maintenance of skeletal muscle plasticity upon changes in the environment, nutrient supply, and exercise depends on regulatory mechanisms that couple structural and metabolic adaptations. However, the transcriptional control of both processes by nuclear receptors (NR) remains underexplored. Nr2f6 is an orphan NR and a key regulator of metabolism and differentiation. Nonetheless, its role in muscle biology remains elusive. Here, we report,...