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  • OER000003046.pdf.jpg
  • Journal article

  • Experimental evidence for enhanced receptor binding by rapidly spreading SARS-CoV-2 variants

    • Authors : Laffeber, Charlie (2021)

  • Rapidly spreading new variants of SARS-CoV-2 carry multiple mutations in the viral spike protein which attaches to the angiotensin converting enzyme 2 (ACE2) receptor on host cells. Among these mutations are amino acid changes N501Y (lineage B.1.1.7, first identified in the UK), and the combination N501Y, E484K, K417N (B.1.351, first identified in South Africa), all located at the interface on the receptor binding domain (RBD). We expe...