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Browsing by Subject hemophilia A

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Journal article

Low normal factor V enhances thrombin generation in hemophilia A by a substrate competition mechanism with factor Xa

Authors : Monroe, Dougald M. (2023)

Bleeding patterns in people with hemophilia A cannot be predicted solely by factor VIII (FVIII) levels. Some of the variance in bleeding may be attributed to differences in plasma protein composition, and specifically other coagulation factors where the normal ranges span 50-150% of the population mean. We recently used a mathematical model of thrombus formation that identified factor V (FV) levels as a strong modifier of thrombin ...