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Ebooks (Sách điện tử)

Identification of the intracellular protein targets of a bio-active clickable half-sandwich iridium complex by chemical proteomics

Authors : Ramos, Robin (2023)

Identification of intracellular targets of anticancer drug candidates provides key information on their mechanism of action. Exploiting the ability of the anticancer (C^N)-chelated half-sandwich iridium(III) complexes to covalently bind proteins, click chemistry with a bioorthogonal azido probe was used to localize a phenyloxazoline-chelated iridium complex within cells and profile its interactome at the proteome-wide scale. Proteins involved in protein folding and...

Journal Article

Probing Bioactive Chemical Space to Discover RNA-Targeted Small Molecules

Authors : wicks, sarah L. (2023)

The use of small molecules to modulate RNA structure and function has become invaluable for studying the many roles of RNA in biological processes1 as well as discovering effective therapeutic treatments.2-5 Early on, the promise of RNA as a ‘druggable’ target was demonstrated by the identification of several RNA-targeting small molecule classes such as aminoglycosides.6, 7 These ligands bound highly abundant and structured ribosomal RNA (r...