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Journal article

A targeted isotope dilution mass spectrometry assay for Osteopontin quantification in plasma of metastatic breast cancer patients

Authors : Leslie, Andrew (2023)

Osteopontin (OPN) is a secreted glycophosphoprotein that derives its name from its high abundance in 33 bone and secretion by osteoblasts. It is also secreted by a number of immune cells and, therefore, is 34 present in human plasma at nanogram per millilitre levels where it affects cell adhesion and motility. 35 These properties implicate OPN as a promotor of tumor progression. Plasma OPN is primarily measured 36 by enz...

Journal article

Low normal factor V enhances thrombin generation in hemophilia A by a substrate competition mechanism with factor Xa

Authors : Monroe, Dougald M. (2023)

Bleeding patterns in people with hemophilia A cannot be predicted solely by factor VIII (FVIII) levels. Some of the variance in bleeding may be attributed to differences in plasma protein composition, and specifically other coagulation factors where the normal ranges span 50-150% of the population mean. We recently used a mathematical model of thrombus formation that identified factor V (FV) levels as a strong modifier of thrombin ...

Journal article

Pre-analytical processing of plasma and serum samples for combined proteome and metabolome analysis

Authors : Gegner, Hagen M. (2023)

Metabolomic and proteomic analyses of human plasma and serum samples harbour the power to advance our understanding of disease biology. Pre-analytical factors may contribute to variability and bias in the detection of analytes, especially when multiple labs are involved, caused by sample handling, processing time, and differing operating procedures. To better understand the impact of pre-analytical factors that are relevant to implement a unified proteomic and...