Journal articleAuthors : Munhoz, Ana Cláudia (2023)
Obesity significantly decreases life expectancy and increases the incidence of age-related dysfunctions, including -cell dysregulation leading to inadequate insulin secretion. Here, we show that diluted plasma from obese human donors acutely impairs -cell integrity and insulin secretion relative to plasma from lean subjects. Similar results were observed with diluted sera from obese rats fed ad libitum, when compared to sera from lean, calorically-restricted, animals.... 
