Ebooks (Sách điện tử)Authors : Ramos, Robin (2023)
Identification of intracellular targets of anticancer drug candidates provides key information on
their mechanism of action. Exploiting the ability of the anticancer (C^N)-chelated half-sandwich
iridium(III) complexes to covalently bind proteins, click chemistry with a bioorthogonal azido probe
was used to localize a phenyloxazoline-chelated iridium complex within cells and profile its
interactome at the proteome-wide scale. Proteins involved in protein folding and... 
