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Showing results 1 to 4 of 4
  • OER000003003.pdf.jpg
  • Journal article

  • CM1-driven assembly and activation of Yeast γ-Tubulin Small Complex underlies microtubule nucleation

    • Authors : Brilot, Axel F. (2021)

  • Microtubule (MT) nucleation is regulated by the γ-tubulin ring complex (γTuRC), conserved from yeast to humans. In Saccharomyces cerevisiae, γTuRC is composed of seven identical γ-tubulin small complex (γTuSC) sub-assemblies which associate helically to template microtubule growth. γTuRC assembly provides a key point of regulation for the MT cytoskeleton. Here we combine cross-linking mass spectrometry (XL-MS), X-ray crystallography and cryo-EM structures of both monomeric&...
  • OER000002745.pdf.jpg
  • Journal article

  • Distinct glycerophospholipids potentiate Gsα-activated adenylyl cyclase activity

    • Authors : Seth, Anubha (2023)

  • Nine mammalian adenylyl cyclases (AC) are pseudoheterodimers with two hexahelical 29 membrane domains which are isoform-specifically conserved. Previously we proposed that these 30 membrane domains are orphan receptors (10.7554/eLife.13098; 10.1016/j.cellsig.2020.109538). 31 Lipids extracted from fetal bovine serum at pH 1 inhibited several mAC activities. Guided by a 32 lipidomic analysis we tested glycerophospholipids as potential ligands. Contrary to expectations 33 we s...
  • OER000002545.pdf.jpg
  • Industry article

  • Structural and mechanistic insights into activation of the human RNA ligase RTCB by Archease

    • Authors : gerber, janina Lara (2023)

  • RNA ligases of the RTCB-type play an essential role in tRNA splicing, the unfolded protein response and RNA repair. RTCB is the catalytic subunit of the pentameric human tRNA ligase complex. RNA ligation by the tRNA-ligase complex requires GTP-dependent activation of RTCB. This active site guanylylation reaction relies on the activation factor Archease. The mechanistic interplay between both proteins has remained unknown. Here, we report a&...
  • OER000002640.pdf.jpg
  • Journal article

  • Structural insights into agonist-binding and activation of the human complement C3a receptor

    • Authors : Yadav, Manish K. (2023)

  • The complement cascade is an integral part of innate immunity, and it plays a crucial role in our body's innate immune response including combating microbial infections. Activation of the complement cascade results in the generation of multiple peptide fragments, of which complement C3a and C5a are potent anaphylatoxins. The complement C3a binds and activates a G protein-coupled receptor (GPCR) known as C3aR while C5a activates two distinct receptors...