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  • OER000003018.pdf.jpg
  • Journal article

  • A novel heteromeric pantothenate kinase complex in apicomplexan parasites

    • Authors : Tjhin, Erick T. (2021)

  • Coenzyme A is synthesised from pantothenate via five enzyme-mediated steps. The first step is catalysed by pantothenate kinase (PanK). All PanKs characterised to date form homodimers. Many organisms express multiple PanKs. In some cases, these PanKs are not functionally redundant, and some appear to be non-functional. Here, we investigate the PanKs in two pathogenic apicomplexan parasites, Plasmodium falciparum and Toxoplasma gondii. Each of these organisms expres...
  • OER000002316.pdf.jpg
  • Journal Article

  • Beyond the MEP Pathway: a novel kinase required for prenol utilization by malaria parasites

    • Authors : Crispim, Marcell (2023)

  • Plasmodium falciparum causes the most severe form of human malaria, a parasitic disease with a high global burden. In 2021, the World Health Organization reported an estimated 247 million cases of malaria and 619,000 malaria-related deaths, with the majority occurring among children and pregnant women in Sub-Saharan Africa. In 2021, 96% of all malaria-related deaths occurred in this region. Resistance to current antimalarial drugs is a signi...