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Journal article

“Antimicrobial Properties and Physical Characteristics of Essential Oil Extracted from Artemisia herba alba Collected in El Bayadh, Algeria”

Authors : mahmoud Dif, Mustapha (2023)

Artemisia herba-alba is a white mugwort harvested in the Bougtobe region of the El-Bayad province. Essential oils were extracted from the plant using hydrodistillation. The antibacterial study of Artemisia herba-alba essential oils revealed a significant inhibitory action on the growth of tested microorganisms including Bacillus cereus, Staphylococcus aureus. These results demonstrated significant activity compared to the positive control penicillin, amoxicillin,&...

Journal Article

Deep mutational scanning and machine learning uncover antimicrobial peptide features driving membrane selectivity

Authors : Randall, Justin R. (2023)

Host-defense peptides are an evolutionarily conserved group of natural antimicrobial peptides which fight pathogens through direct antimicrobial activity and/or by modulating the host immune response during infection1. Antibacterial host-defense peptides generally kill bacteria directly through cell membrane disruption, but many show difficulties differentiating bacterial and mammalian cell membranes, complicating clinical use. Though some aspects of membrane selectivity have been describ...

Journal article

Structural characterization of the antimicrobial peptides myxinidin and WMR in bacterial membrane mimetic micelles and bicelles

Authors : Cherniavskyi, Yevhen K. (2021)

Antimicrobial peptides are a promising class of alternative antibiotics that interact selectively with negatively charged lipid bilayers. This paper presents the structural characterization of the antimicrobial peptides myxinidin and WMR associated with bacterial membrane mimetic micelles and bicelles by NMR, CD spectroscopy, and Molecular Dynamics simulations. Both peptides adopt a different conformation in the lipidic environment than in aqueous solution. The...