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Showing results 1 to 7 of 7
  • OER000002757.pdf.jpg
  • Journal article

  • Clearing of ribosome collisions by the ribosome quality control trigger complex RQT

    • Authors : Best, Katharina (2023)

  • After translational stalls, colliding eukaryotic ribosomes are cleared through dissociation into subunits by the ribosome quality control trigger complex, RQT, by an unknown mechanism. Here we show that RQT requires accessible mRNA and the presence of a neighboring ribosome. Cryo-EM of several RQT-ribosome complexes revealed the structural basis of splitting: RQT engages the 40S subunit of the lead ribosome and can switch between two conformations. We propose...
  • OER000002567.pdf.jpg
  • Journal article

  • Dynamic lid domain of Chloroflexus aurantiacus Malonyl-CoA Reductase controls the reaction

    • Authors : Kabasakal, Burak V. (2023)

  • Malonyl-Coenzyme A Reductase (MCR) in Chloroflexus aurantiacus, a characteristic enzyme of the 3-hydroxypropionate (3-HP) cycle, catalyses the reduction of malonyl-CoA to 3-HP. MCR is a bi-functional enzyme; in the first step, malonyl-CoA is reduced to the free intermediate malonate semialdehyde by the C-terminal region of MCR, and further reduced to 3-HP by the N-terminal region of MCR. Here we present the crystal structures of both N-�...
  • OER000002431.pdf.jpg
  • Ebooks (Sách điện tử)

  • Na+/H+ antiporter activity by respiratory complex I controls mitochondrial Δψ and is impaired in LHON disease

    • Authors : Agustín, Pablo Hernansanz (2023)

  • The mitochondrial electron transport chain (mETC) converts the energy of substrate oxidation into a H+ electrochemical gradient (Δp), which is composed by an inner mitochondrial membrane (IMM) potential (ΔΨmt) and a pH gradient (ΔpH). So far, ΔΨmt has been assumed to be composed exclusively by H+. Mitochondrial Ca2+ and Na+ 15 homeostasis, which are essential for cellular function, are controlled by exchangers and antiporters in the inner mitochondrial&#...
  • OER000002607.pdf.jpg
  • Journal article

  • Phosphorylation controls spatial and temporal activities of motor-PRC1 complexes to complete mitosis

    • Authors : Kustusz, Agata Gluszek (2023)

  • During mitosis, spindle architecture alters as chromosomes segregate to daughter cells. The microtubule crosslinker Protein Required for Cytokinesis 1 (PRC1) is essential for spindle stability, chromosome segregation and completion of cytokinesis, but how it recruits motors to the central spindle to coordinate the segregation of chromosomes is unknown. Here, we combine structural and cell biology approaches to show that the human CENP-E motor, which&...
  • OER000001833-1.pdf.jpg
  • Ebooks (Sách điện tử)

  • Production Engineering and Robust Control

    • Authors : Tolouei-Rad, Majid (2022)

  • Production engineering and advanced control systems make it possible to respond to the increasing needs of nations around the world. This book presents some of the new ideas, creative applications, and process optimization methods for more efficient utilization of resources available for improving productivity and reliability or lessening the times and costs of industrial production processes. It presents a variety of chapters on the development of production...
  • OER000002454.pdf.jpg
  • Journal Article

  • Sterols from cholesterol synthesis control distinct gene regulatory pathways

    • Authors : Skubic, Cene (2023)

  • Sterol intermediates of cholesterol synthesis are largely dedicated to cholesterol. Here we assess how they influence downstream gene regulatory pathways by developing knockouts (KOs) for consecutive enzymes of cholesterol synthesis. Depletion of CYP51, DHCR24 and SC5D resulted in accumulation of specific sterols. The overlap of deregulated genes was only 9% in terms of steroid metabolism and proliferation control, with majority of pathways changed i...
  • OER000002726.pdf.jpg
  • Journal article

  • Translational Activity Controls Ribophagic Flux and Turnover of Distinct Ribosome Pools

    • Authors : Trendel, Jakob (2023)

  • Ribosomes are among the most abundant and complex machineries in the cell, however, the turnover 15 of their subunits remains poorly understood. Here, we apply proteomic flux and cryo-electron 16 microscopy analyses to interrogate the ribosome life cycle in human cells. We show that subpopulations 17 of ribosomal subunits coexist, which vary in turnover kinetics and structure. Specifically, 80S ribosomes 18 have a much longer half-life than free 40S...