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  • OER000002980.pdf.jpg
  • Journal article

  • Stem cell quiescence requires PRC2/PRC1-mediated mitochondrial checkpoint

    • Authors : Ishibashi, JR (2021)

  • Both normal and tumorous stem cells can arrest cell division, avoid apoptosis, and then regenerate lost daughter cells following acute genotoxic insult. This protective, reversible proliferative arrest, known as “quiescence,” is still poorly understood. Here, we show that mTOR-regulated mitophagy is required for radiation insult-induced quiescence in Drosophila germline stem cells (GSCs). In GSCs, depletion of mito-fission (Drp1) or mitophagy �...