Digital resources - Ha Noi university of science and technology

Browsing by Subject kinase HRI

Jump to: 0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
or enter first few letters:

Showing results 1 to 1 of 1

Journal article

Genetic screening identifies integrated stress response kinase HRI (EIF2AK1) as a negative regulator of PINK1 and mitophagy signalling

Authors : Singh, Pawan Kishor (2023)

Loss of function mutations of the PINK1 kinase cause familial early-onset Parkinson’s disease. PINK1 is activated upon mitochondrial damage to phosphorylate Ubiquitin and Parkin to trigger removal of damaged mitochondria by autophagy (mitophagy). PINK1 also indirectly phosphorylates a subset of Rab GTPases including Rab8A. We have performed a siRNA screen of all human Ser/Thr kinases in HeLa cells and discovered the integrated stress respo...