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  • OER000002427.pdf.jpg
  • Ebooks (Sách điện tử)

  • A TREX1 model reveals double-strand DNA preference and inter-protomer regulation

    • Authors : Hemphill, Wayne O. (2023)

  • The TREX1 3’ à 5’ exonuclease degrades DNA in vivo to prevent chronic immune activation through the cGAS-STING pathway. TREX1 degrades ss- and dsDNA containing a free 3’-hydroxyl, but the precise nature of immune-activating DNA remains an open question. The TREX1 homodimer structure is critical for exonuclease activity with amino acids from one protomer acting across the dimer interface contributing to catalysis in the opposing protomer.&#x...
  • OER000002412.pdf.jpg
  • Ebooks (Sách điện tử)

  • Diversity of function and higher-order structure within HWE sensor histidine kinases

    • Authors : Dikiy, Igor (2023)

  • Integral to the protein structure/function paradigm, oligomeric state is typically conserved 31 along with function across evolution. However, notable exceptions such as the hemoglobins 32 show how evolution can alter oligomerization to enable new regulatory mechanisms. Here we 33 examine this linkage in histidine kinases (HKs), a large class of widely distributed prokaryotic 34 environmental sensors. While the majority of HKs are transmembrane ...