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  • OER000002973.pdf.jpg
  • Journal article

  • Structures of a deAMPylation complex rationalise the switch between antagonistic catalytic activities of FICD (14/96/109)

    • Authors : Perera, Luke A. (2021)

  • The endoplasmic reticulum (ER) Hsp70 chaperone BiP is regulated by AMPylation, a reversible inactivating post-translational modification. Both BiP AMPylation and deAMPylation are catalysed by a single ER-localised enzyme, FICD. Here we present long-sought crystallographic and solution structures of a deAMPylation Michaelis complex formed between mammalian AMPylated BiP and FICD. The latter, via its tetratricopeptide repeat domain, binds a surface that is specific&#x...