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Showing results 1 to 7 of 7
  • OER000003012.pdf.jpg
  • Journal article

  • A distinct assembly pathway of the human 39S late pre-mitoribosome

    • Authors : Cheng, Jingdong (2021)

  • Assembly of the mitoribosome is largely enigmatic and involves numerous assembly factors. However, little is known about their function and the architectural transitions of the pre-ribosomal intermediates. Here, we solved cryo-EM structures of the human 39S large subunit pre-ribosomes, representing four distinct late state intermediates. Besides the MALSU1 complex, we identified several assembly factors, including the DDX28 helicase, MRM3, GTPBP10 and th...
  • OER000001945-1.pdf.jpg
  • Ebooks (Sách điện tử)

  • Applications of Design for Manufacturing and Assembly

    • Authors : Păcurar, Ancuta Carmen (2019)

  • The book entitled Application of Design for Manufacturing and Assembly aims to present applicable research in the field of design, manufacturing, and assembly realized by researchers affiliated to well-known institutes. The book has a profound interdisciplinary character and is addressed to researchers, engineers, PhD students, graduate and undergraduate students, teachers, and other readers interested in assembly applications. I am confident that readers will find int...
  • OER000003003.pdf.jpg
  • Journal article

  • CM1-driven assembly and activation of Yeast γ-Tubulin Small Complex underlies microtubule nucleation

    • Authors : Brilot, Axel F. (2021)

  • Microtubule (MT) nucleation is regulated by the γ-tubulin ring complex (γTuRC), conserved from yeast to humans. In Saccharomyces cerevisiae, γTuRC is composed of seven identical γ-tubulin small complex (γTuSC) sub-assemblies which associate helically to template microtubule growth. γTuRC assembly provides a key point of regulation for the MT cytoskeleton. Here we combine cross-linking mass spectrometry (XL-MS), X-ray crystallography and cryo-EM structures of both monomeric&...
  • OER000002688.pdf.jpg
  • Journal article

  • Structural basis for RNA-mediated assembly of type V CRISPR-associated transposons

    • Authors : Schmitz, Michael (2023)

  • CRISPR systems have been co-opted by Tn7-like elements to direct RNA-guided transposition. Type V-K CRISPR-associated transposons rely on the concerted activities of the pseudonuclease Cas12k, the AAA+ ATPase TnsC, the Zn-finger protein TniQ, and the transposase TnsB. Here we present a cryo-electron microscopic structure of a target DNA-bound Cas12k-transposon recruitment complex comprising RNA-guided Cas12k, TniQ, TnsC and, unexpectedly, the ribosomal protein ...
  • OER000002776.pdf.jpg
  • Journal article

  • Structural basis of actin filament assembly and aging

    • Authors : Oosterheert, Wout (2023)

  • The dynamic turnover of actin filaments (F-actin) controls cellular motility in eukaryotes and is coupled to changes in the F-actin nucleotide state. It remains unclear how F-actin hydrolyzes ATP and subsequently undergoes subtle conformational rearrangements that ultimately lead to filament depolymerization by actin-binding proteins. Here, we present cryo-EM structures of F-actin in all nucleotide states, polymerized in the presence of Mg2+ or Ca2+, ...
  • OER000002956.pdf.jpg
  • Journal article

  • Three ParA dimers cooperatively assemble on type Ia partition promoters

    • Authors : Boudsocq, François (2021)

  • Accurate DNA segregation is essential for faithful inheritance of genetic material. In bacteria, this process is mainly ensured by a partition system (Par) composed of two proteins, ParA and ParB, and a centromere site. The auto-regulation of Par operon expression is important for efficient partitioning, and is primarily mediated by ParA for type Ia plasmid partition systems. For the plasmid F, four ParAF monomers were proposed to ...