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Showing results 1 to 5 of 5

Journal Article

Downregulation of CYP7B1 caused by lipotoxicity associates with the progression of non-alcoholic steatohepatitis

Authors : Watanabe, Yuichi (2023)

Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide, with an incidence of >25% of the adult population. NAFLD ranges from benign simple steatosis to non-alcoholic steatohepatitis (NASH). However, its transition mechanisms underlying the pathogenesis remain to be clarified. The expression of Cyp7b1 gene is downregulated in the liver of leptin-deficient mice and methionine and choline-deficient diet-fed mice based on previous&#...

Journal article

Lipid mediator profile of burn wound healing: Acellular cod fish skin grafts promote the formation of EPA and DHA derived lipid mediators during the first seven days

Authors : Kotronoulas, Aristotelis (2021)

The use of acellular fish skin grafts (FSG) for the treatment of burn wounds is becoming more common due to its beneficial wound healing properties. In our previous study we demonstarted that FSG is a scaffold biomaterial that is rich in eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) conjugated to phosphatidylcholines. Here we investigated whether EPA and DHA derived lipid mediators are influenced during the&#...

Journal article

Lipid nanodiscs as a template for high-resolution cryo-EM structures of peripheral membrane proteins

Authors : Cannon, Kevin S. (2023)

processes such as signal transduction, membrane trafficking, and autophagy. Transient binding to the membrane has a profound impact on protein function, serving to induce conformational changes and alter biochemical and biophysical parameters by increasing the local concentration of factors and restricting diffusion to two dimensions. Despite the centrality of the membrane in serving as a template for cell biology, there are few reported highresolution stru...

Journal article

Lipid signatures and inter-cellular heterogeneity of naïve and lipopolysaccharide-stimulated human microglia-like cells

Authors : Müller, Max A. (2023)

Microglia are non-neuronal cells, which are residing in the central nervous system and are known to play an important role in health and disease. We investigated lipidomic phenotypes of human naïve and stimulated microglia-like cells by atmospheric-pressure scanning microprobe matrix-assisted laser desorption/ionization mass spectrometry imaging (AP-SMALDI MSI). With lateral resolutions between 5 μm and 1.5 μm, we were able to chart lipid compositions of individua...

Journal article

Retention dependences support highly confident identification of lipid species in human plasma by reversed-phase UHPLC/MS

Authors : Vaňková, Zuzana (2023)

Reversed-phase ultrahigh-performance liquid chromatography – mass spectrometry (RP-UHPLC/MS) method was developed with the aim to unambiguously identify a large number of lipid species from multiple lipid classes in human plasma. The optimized RP-UHPLC/MS method employed the C18 column with sub-2 μm particles with the total run time of 25 min. Thechromatographic resolution was investigated with 42 standards from 18 lipid classes. The UHPLC system was cou...