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  • OER000002747.pdf.jpg
  • Journal article

  • Inhibiting succinate release worsens cardiac reperfusion injury by enhancing mitochondrial reactive oxygen species generation

    • Authors : Milliken, Alexander S. (2023)

  • The metabolite succinate accumulates during cardiac ischemia. Within 5 min. of 22 reperfusion, succinate returns to baseline levels via both its release from cells and oxidation by 23 mitochondrial complex II (Cx-II). The latter drives reactive oxygen species (ROS) generation and 24 subsequent opening of the mitochondrial permeability transition (PT) pore, leading to cell death. 25 Targeting succinate dynamics (accumulation/oxidation/release) may be therapeutically...