Journal articleAuthors : Saha, Kaushik (2021)
The specific recognition of splice signals at or near exon-intron junctions is not explained by their
weak conservation and instead is postulated to require a multitude of features embedded in the
pre-mRNA strand. We explored the possibility of three-dimensional structural scaffold of AdML – a
model pre-mRNA substrate – guiding early spliceosomal components to the splice signal
sequences. We find that mutations in the non...