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  • OER000002694.pdf.jpg
  • Journal article

  • N1-Methylpseudouridine and pseudouridine modifications modulate mRNA decoding during translation

    • Authors : Monroe, Jeremy G. (2023)

  • rapid and accurate protein production. The inclusion of chemically modified bases into mRNAs has the potential to alter the strength and pattern of hydrogen bonding between mRNAs and aminoacyl-tRNAs to alter protein synthesis. We investigated how the N1-methylpseudouridine (m1Y) modification, commonly incorporated into therapeutic and vaccine mRNA sequences, influences the ability of codons to react with cognate and near-cognate tRNAs and release factors. We find ...
  • OER000002658.pdf.jpg
  • Journal article

  • Structural basis for reduced ribosomal A-site fidelity in response to P-site codon-anticodon mismatches

    • Authors : Nguyen, Ha An (2023)

  • Rapid and accurate translation is essential in all organisms to produce properly folded and functional proteins. mRNA codons that define the protein coding sequences are decoded by tRNAs on the ribosome in the aminoacyl (A) binding site. The mRNA codon and the tRNA anticodon interaction is extensively monitored by the ribosome to ensure accuracy in tRNA selection. While other polymerases that synthesize DNA and RNA can correct for...