Journal articleAuthors : Srinivas, Pooja (2023)
Acquired ribosomal RNA (rRNA) methylation has emerged as a significant mechanism of aminoglycoside
resistance in pathogenic bacterial infections. Modification of a single nucleotide in the ribosome decoding
center by the aminoglycoside-resistance 16S rRNA (m7G1405) methyltransferases effectively blocks the
action of all 4,6-deoxystreptamine ring-containing aminoglycosides, including the latest generation of drugs.
To define the molecular basis of 30S subunit recognition ... 
