Journal articleAuthors : Pergu, Rajaiah (2023)
Chimeric small molecules that induce post-translational modification (PTM) on a target protein by bringing it in
proximity to a PTM-inducing enzyme are furnishing novel modalities to perturb protein function. Despite recent
advances, such molecules are unavailable for a critical PTM, tyrosine phosphorylation. Furthermore, the
contemporary design paradigm of chimeric molecules, formed by joining a non-inhibitory binder of the PTMinducing
enzyme with the bi... 
