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  • OER000002550.pdf.jpg
  • Journal article


  • Authors : Gruzdev, Nadya (2023)

  • Methionine is an essential amino acid in mammals and a critical metabolite in all organisms. As such, various applications, including food, feed, and pharmaceuticals, necessitate the addition of L-methionine. Although amino acids and other metabolites are commonly produced through bacterial fermentation, high-yield biosynthesis of L-methionine remains a significant challenge due to the strict cellular regulation of the biosynthesis pathway. As a result,&...

  • OER000002552.pdf.jpg
  • Journal article


  • Authors : Lim, Roktaek (2023)

  • The Michaelis–Menten (MM) rate law has been the dominant paradigm of modeling23 biochemical rate processes for over a century with applications in biochemistry, biophysics,24 cell biology, and chemical engineering. The MM rate law and its remedied form stand on the25 assumption that the concentration of the complex of interacting molecules, at each moment,26 approaches an equilibrium much faster than the molecular concentrations change. Yet, thi...