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  • OER000002512.pdf.jpg
  • Journal article

  • Pyroptosis inhibiting nanobodies block Gasdermin D pore formation

    • Authors : Kopp, Anja  (2023)

  • Gasdermin D (GSDMD) is a key mediator of pyroptosis, a pro-inflammatory form of cell death 10 occurring downstream of inflammasome activation as part of the innate immune defence. Upon cleavage by inflammatory caspases, the N-terminal domain of GSDMD forms pores in the plasma membrane resulting in cytokine release and eventually cell death. Targeting GSDMD is an attractive way to dampen inflammation. In this study, six GSDMD targeting nanobodies wer...
  • OER000002548.pdf.jpg
  • Journal article

  • Utilizing a nanobody recruitment approach for assessing serine palmitoyltransferase activity in ER sub-compartments of yeast

    • Authors : Esch, Bianca M. (2023)

  • Sphingolipids (SP) are one of the three major lipid classes in eukaryotic cells and serve as38 structural components of the plasma membrane. The rate-limiting step in SP biosynthesis is39 catalyzed by serine palmitoyltransferase (SPT). In yeast, SPT consists of two catalytic subunits40 (Lcb1 and Lcb2), a regulatory subunit (Tsc3), negative regulators (Orm1 and Orm2), and the41 phosphatidylinositol-4-phosphate (PI4P) phosphatase Sac1, collectively known as...