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  • OER000002642.pdf.jpg
  • Journal article

  • Arachidonic acid does not grease the exocytotic SNARE machinery

    • Authors : Fasshauer, Dirk (2023)

  • It has been proposed that arachidonic acid stimulates neurite outgrowth by specifically activating syntaxin 3, a SNARE proteins that mediates the fusion of transport vesicles with the plasma membrane and is thus instrumental for the insertion of new membrane needed for cell growth and proliferation. Considering the important role of arachidonic acid and other polyunsaturated fatty acids for human health, these findings would have wide implications for ev...
  • OER000002550.pdf.jpg
  • Journal article

  • Conversion of methionine biosynthesis in E. coli from trans- to direct-sulfurylation enhances extracellular methionine levels

    • Authors : Gruzdev, Nadya (2023)

  • Methionine is an essential amino acid in mammals and a critical metabolite in all organisms. As such, various applications, including food, feed, and pharmaceuticals, necessitate the addition of L-methionine. Although amino acids and other metabolites are commonly produced through bacterial fermentation, high-yield biosynthesis of L-methionine remains a significant challenge due to the strict cellular regulation of the biosynthesis pathway. As a result,&...
  • OER000002719.pdf.jpg
  • Journal article

  • Sulfotyrosine, an interaction specificity determinant for extracellular protein-protein interactions

    • Authors : Stewart, Valley (2023)

  • Tyrosine sulfation, a post-translational modification, can enhance and often determine protein-protein interaction specificity. Sulfotyrosyl residues (sTyr) are formed by tyrosylprotein sulfotransferase during maturation in the golgi apparatus, and most often occur singly or as a cluster of two or three sTyr within a six-residue span. With both negative charge and aromatic character, sTyr enables numerous atomic contacts as visualized in binding interfac...