Digital resources - Ha Noi university of science and technology

Browsing by Subject oxy phản ứng

Jump to: 0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
or enter first few letters:

Showing results 1 to 4 of 4

Journal Article

3-hydroxykynurenine is a ROS-inducing cytotoxic tryptophan metabolite that disrupts the TCA cycle

Authors : Buchanan, Jane L. (2023)

Tryptophan is an essential amino acid that is extensively characterized as a regulator of cellular function through its metabolism by indoleamine 2,3-deoxygenase (IDO) into the kynurenine pathway. However, despite decades of research on tryptophan metabolism, the metabolic regulatory roles of it and its metabolites are not well understood. To address this, we performed an activity metabolomics screen of tryptophan and most of its known metabolit...

Journal Article

A cautionary note on the use of N-acetylcysteine as a reactive oxygen species antagonist to assess copper mediated cell death

Authors : Graham, ebecca E. (2023)

A new form of cell death has recently been proposed involving copper-induced cell death, termed cuproptosis. This new form of cell death has been widely studied in relation to a novel class of copper ionophores, including elesclomol and disulfiram. However, the exact mechanism leading to cell death remains contentious. The oldest and mostly widely accepted biological mechanism is that the accumulated intracellular copper leads ...

Journal article

Electrochemical measurements reveal reactive oxygen species in stress granules

Authors : Hu, Keke (2021)

Stress granules (SGs) are membraneless organelles that assemble in the cytoplasm to organize cellular contents and promote rapid adaptation during stress. To understand how SGs contribute to physiological functions, we used electrochemical measurements to detect electroactive species in SGs. With amperometry, we discovered that reactive oxygen species (ROS) are encapsulated inside arseniteinduced SGs, and H2O2 is the main species. The release kinetics of&...

Journal article

Inhibiting succinate release worsens cardiac reperfusion injury by enhancing mitochondrial reactive oxygen species generation

Authors : Milliken, Alexander S. (2023)

The metabolite succinate accumulates during cardiac ischemia. Within 5 min. of 22 reperfusion, succinate returns to baseline levels via both its release from cells and oxidation by 23 mitochondrial complex II (Cx-II). The latter drives reactive oxygen species (ROS) generation and 24 subsequent opening of the mitochondrial permeability transition (PT) pore, leading to cell death. 25 Targeting succinate dynamics (accumulation/oxidation/release) may be therapeutically...