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Journal Article

Structural basis for competitive binding of productive and degradative co-transcriptional effectors to the nuclear cap-binding complex

Authors : Dubiez, Etienne (2023)

The nuclear cap-binding complex (CBC) co-ordinates co-transcriptional maturation, transport, or degradation of nascent Pol II transcripts. CBC with its partner ARS2 form mutually exclusive complexes with diverse ‘effectors’ that promote either productive or destructive outcomes. Combining Alphafold predictions with structural and biochemical validation, we show how effectors NCBP3, NELF-E, ARS2, PHAX and ZC3H18 form competing binary complexes with CBC and how...