Journal articleAuthors : Stoeber, Jonathan (2021)
α-Synuclein (αS) is an intrinsically disordered protein (IDP) that aggregates into amyloid fibrils
during the progression of Parkinson’s Disease and other synucleinopathies. The N-terminal
domain (residues 1-60) is now understood to play a critical role in the initial nucleation of
aggregation, as well as a pivotal role in the monomer-fibril interaction underlying amyloid seeding.
Here we report on the interaction between αS and...