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  • OER000002707.pdf.jpg
  • Journal article

  • G protein βγ subunits bind to and inhibit the function of multiple Qa- and Qb,c-SNARE isoforms

    • Authors : Zurawski, Zack (2023)

  • While the ability of G protein βγ subunits (Gβγ) to bind to and functionally inhibit the neuronal SNARE proteins Stx1A, SNAP25, and synaptobrevin in the presence of the calcium sensor synaptotagmin I is well documented, these three SNARE proteins, which form the core SNARE complex for synchronous evoked release in neurons, are but a subset of the larger family of SNARE proteins, which participate in many other exocytic proces...
  • OER000002944.pdf.jpg
  • Journal article

  • Selective G protein signaling driven by Substance P-Neurokinin Receptor structural dynamics

    • Authors : Harris, Julian A. (2023)

  • The neuropeptide Substance P (SP) is important in pain and inflammation. SP activates the neurokinin-1 receptor (NK1R) to signal via Gqand Gs proteins. Neurokinin A also activates NK1R, but leads to selective Gq signaling. How two stimuli yield distinct G-protein signaling at the same G-protein-coupled-receptor remains unclear. We determined cryo-EM structures of active NK1R bound to SP or the Gq-biased peptide SP6-11. Peptide interactions deep within NK1R&#x...