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Browsing by Subject protein disulfide isomerase

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Journal article

Mechano-redox control of Mac-1 de-adhesion from ICAM-1 by protein disulfide isomerase promotes directional movement of neutrophils under flow

Authors : Dupuy, Alexander (2023)

Macrophage-1 antigen or Mac-1 (CD11b/CD18, αMβ2) is a leukocyte integrin essential for firm 20 adhesion of neutrophils, lymphocytes and monocytes against flow when recruited to the 21 endothelium. To migrate to the site of inflammation, leukocytes require coordinated adhesion 22 and de-adhesion for directional movement. The vascular thiol isomerase, protein disulfide 23 isomerase (PDI), was found by fluorescence microscopy to colocalize with high...