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Journal article

A metabolic labeling-based chemoproteomic platform unravels the physiological roles of choline metabolites

Authors : Dixit, Aditi (2023)

Choline is an essential nutrient for mammalian cells. Our understanding of the cellular functions of choline and its metabolites, independent of their roles as choline lipid metabolism intermediates, remains limited. In addition to fundamental cellular physiology, this knowledge has implications for cancer biology because elevated choline metabolite levels are a hallmark of cancer. Here, we establish the mammalian choline metabolite-interacting proteome by...

Ebooks (Sách điện tử)

Identification of the intracellular protein targets of a bio-active clickable half-sandwich iridium complex by chemical proteomics

Authors : Ramos, Robin (2023)

Identification of intracellular targets of anticancer drug candidates provides key information on their mechanism of action. Exploiting the ability of the anticancer (C^N)-chelated half-sandwich iridium(III) complexes to covalently bind proteins, click chemistry with a bioorthogonal azido probe was used to localize a phenyloxazoline-chelated iridium complex within cells and profile its interactome at the proteome-wide scale. Proteins involved in protein folding and...