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Showing results 1 to 3 of 3

Journal article

A molecular toolbox for ADP-ribosyl binding proteins

Authors : Tsowa, Swen (2021)

Proteins interacting with ADP-ribosyl groups are often involved in disease-related pathways or in viral infections, which makes them attractive targets for the development of inhibitors. Our goal was to develop a robust and accessible assay technology that is suitable for high-throughput screening and applicable to a wide range of proteins acting as either hydrolysing or non-hydrolysing binders of mono and poly-ADP-ribosyl groups. As a fou...

Ebooks (Sách điện tử)

Identification of proteins that bind extracellular microRNAs secreted by the parasitic nematode Trichinella spiralis

Authors : Brown, A. (2023)

Small non-coding RNAs such as microRNAs (miRNAs) are conserved across eukaryotes and play key roles in regulating gene expression. In many organisms, miRNAs are also secreted from cells, often encased within vesicles such as exosomes and sometimes extravesicular. The mechanisms of miRNA secretion, how they are stabilised outside of cells and their functional importance are poorly understood. Recently we characterised the parasitic nematode Trichinella spiralis as&...

Ebooks (Sách điện tử)

Retracing the evolution of a modern periplasmic binding protein

Authors : Michel, Florian (2023)

Investigating the evolution of structural features in modern multidomain proteins helps to understand their immense diversity and functional versatility. The class of periplasmic binding proteins (PBPs) offers an opportunity to interrogate one of the main processes driving diversification: the duplication and fusion of protein sequences to generate new architectures. The symmetry of their two-lobed topology, their mechanism of binding, and the organization...