Journal articleAuthors : Hammarén, Henrik M. (2023)
Post-translational modifications (PTMs) regulate various aspects of protein function,
including degradation. Mass spectrometric methods that rely on pulsed metabolic labeling
are very popular to quantify turnover rates on a proteome-wide scale. Such data have often
been interpreted in the context of protein proteolytic stability. Here, we combine theoretical
kinetic modeling with experimental pulsed stable isotope labeling of amino acids in cell
culture&... 
