Duyệt theo

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Duyệt theo: 0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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  • OER000002743.pdf.jpg
  • Journal article

  • Direct Visualization of Translesion DNA Synthesis Polymerase IV at the Replisome

    • Tác giả : Tuan, Pham Minh (2023)

  • In bacterial cells, DNA damage tolerance is manifested by the action of translesion DNA polymerases that can synthesize DNA across template lesions that typically block the replicative DNA polymerase III. It has been suggested that one of these TLS DNA polymerases, DNA polymerase IV, can either act in concert with the replisome, switching places on the b sliding clamp with DNA polymerase III to bypass the template damage, or&...
  • OER000002339.pdf.jpg
  • Journal Article

  • Distinct phases of cellular signaling revealed by time-resolved protein synthesis

    • Tác giả : Muir, Tom W. (2023)

  • The post-translational regulation of protein function is involved in most cellular processes. As such, synthetic biology tools that operate at this level provide opportunities for manipulating cellular states. Here, we deploy a proximity-triggered protein trans-splicing technology to enable the time-resolved synthesis of target proteins from pre-made parts. The modularity of the strategy allows for the addition or removal of various control elements as&#x...
  • OER000002544.pdf.jpg
  • Journal article

  • Novel glycoside hydrolase family enzymes from Escherichia coli are associated with osmo-regulated periplasmic glucan synthesis

    • Tác giả : Motouchi, Sei (2023)

  • Most Gram-negative bacteria synthesize osmo-regulated periplasmic glucans (OPG) in the periplasm or extracellular space. Many pathogens lose their pathogenicity by knocking out opgG, an OPG-related gene indispensable for OPG synthesis. However, the biochemical functions of OpgG and OpgD, a paralog of OpgG, have not been elucidated. In this report, structural and functional analyses of OpgG and OpgD from Escherichia coli revealed that these proteins are β-1,2-gluca...