Duyệt theo

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Tìm kiếm theo: Chủ đề rFIX

Duyệt theo: 0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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  • Periodicals (Báo – Tạp chí)

  • Analysis of coagulation factor IX in bioreactor cell culture medium predicts yield and quality of the purified product

    • Tác giả : Zacchi, Lucia F; Recinos, Dinora Roche; Pegg, Cassandra L (2020)

  • Coagulation factor IX (FIX) is a highly complex post-translationally modified human serum glycoprotein and a high-value biopharmaceutical. The quality of recombinant FIX (rFIX), especially complete γ-carboxylation, is critical for rFIX clinical efficacy. Changes in bioreactor operating conditions can impact rFIX production and occupancy and structure of rFIX post-translational modifications (PTMs). We hypothesized that monitoring the bioreactor cell culture supernatant with Data Inde...