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  • OER000002580.pdf.jpg
  • Journal article

  • An alphacoronavirus polymerase structure reveals conserved co-factor functions

    • Authors : Anderson, Thomas K. (2023)

  • Coronaviruses are a diverse subfamily of viruses containing pathogens of humans and animals. This subfamily of viruses replicates their RNA genomes using a core polymerase complex composed of viral non-structural proteins: nsp7, nsp8 and nsp12. Most of our understanding of coronavirus molecular biology comes from the betacoronaviruses like SARS-CoV and SARSCoV- 2, the latter of which is the causative agent of COVID-19. In...
  • OER000002715.pdf.jpg
  • Journal article

  • “Replication stalling activates SSB for recruitment of DNA damage tolerance factors”

    • Authors : Thrall, Elizabeth S. (2023)

  • Translesion synthesis (TLS) polymerases bypass DNA lesions that block replicative polymerases, allowing cells to tolerate DNA damage encountered during replication. It is well known that most bacterial TLS polymerases must interact with the sliding clamp processivity factor to carry out TLS, but recent work in Escherichia coli has revealed that single-stranded DNA-binding protein (SSB) plays a key role in enriching the TLS polymerase Pol IV at stalled re...
  • OER000001264.pdf.jpg
  • Book

  • The Amazing Journey of Reason: from DNA to Artificial Intelligence

    • Authors : Alemi, Mario (2020)

  • Life, Energy and Information: What Is Life?, The Decay Towards Equilibrium, Energy Extraction Requires Information...From the Big Bang to Living Cells: Intelligent Systems, Ex-Nihilo Energy and Information, The Emergence of Complexity. From Complex Organisms to Societies: Intelligence Needs Energy, Sleep, Death and Reproduction, The Limits of Unicellular Organisms. The Human Social Brains: Why a More Powerful Brain?, The Primates’ Brain...The Human Meta-Organism: The Evolut...