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  • OER000002287.pdf.jpg
  • Journal Article

  • Flexibility and distributive synthesis regulate RNA priming and handoff in human DNA polymerase α-primase

    • Authors : Cordoba, John J (2023)

  • In eukaryotes, DNA polymerase α-primase (pol-prim) initiates DNA synthesis during replication, generating the first ~30 nucleotides of nascent strands.1–5 Pol-prim is unique among replicative polymerases in its ability to perform de novo synthesis from a single-stranded DNA template; the primers it creates are required for further synthesis by the processive polymerases ε and δ that perform the bulk of nascent strand synthesis6,7. Pol-prim plays a particularly...
  • OER000003041.pdf.jpg
  • Journal article

  • Termination of DNA replication at Tus-ter barriers results in under-replication of template DNA

    • Authors : Jameson, Katie H. (2021)

  • The complete and accurate duplication of genomic information is vital to maintain genome stability in all domains of life. In Escherichia coli, replication termination, the final stage of the duplication process, is confined to the ‘replication fork trap’ region by multiple unidirectional fork barriers formed by the binding of Tus protein to genomic ter sites. Termination typically occurs away from Tus-ter complexes, but they become part&#x...