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Browsing by Subject serine palmitoyltransferase

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Journal article

Utilizing a nanobody recruitment approach for assessing serine palmitoyltransferase activity in ER sub-compartments of yeast

Authors : Esch, Bianca M. (2023)

Sphingolipids (SP) are one of the three major lipid classes in eukaryotic cells and serve as38 structural components of the plasma membrane. The rate-limiting step in SP biosynthesis is39 catalyzed by serine palmitoyltransferase (SPT). In yeast, SPT consists of two catalytic subunits40 (Lcb1 and Lcb2), a regulatory subunit (Tsc3), negative regulators (Orm1 and Orm2), and the41 phosphatidylinositol-4-phosphate (PI4P) phosphatase Sac1, collectively known as...