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  • OER000002408.pdf.jpg
  • Journal Article

  • Characterization and super-resolution imaging of small tau aggregates in human samples

    • Authors : Böken, Dorothea (2023)

  • The hyperphosphorylation and aggregation of the microtubule binding protein tau plays a key role in the development of Alzheimer’s disease and other tauopathies, ultimately resulting in the formation of intracellular tau filaments. While the structure of the filaments formed in humans has recently been determined to atomic resolution, there is far less information available about the smaller aggregates formed in earlier stages of th...
  • OER000002715.pdf.jpg
  • Journal article

  • “Replication stalling activates SSB for recruitment of DNA damage tolerance factors”

    • Authors : Thrall, Elizabeth S. (2023)

  • Translesion synthesis (TLS) polymerases bypass DNA lesions that block replicative polymerases, allowing cells to tolerate DNA damage encountered during replication. It is well known that most bacterial TLS polymerases must interact with the sliding clamp processivity factor to carry out TLS, but recent work in Escherichia coli has revealed that single-stranded DNA-binding protein (SSB) plays a key role in enriching the TLS polymerase Pol IV at stalled re...