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Showing results 1 to 13 of 13
  • OER000002653.pdf.jpg
  • Journal article

  • A general strategy to develop fluorogenic polymethine dyes for bioimaging

    • Authors : Martin, Annabell (2023)

  • Fluorescence imaging is an invaluable tool to study biological processes and further progress depends on the development of advanced probes. Fluorogenic dyes are crucial to reach intracellular targets and label them with high specificity. Excellent fluorogenic rhodamine dyes have been reported, but they often require a long and lowyielding synthesis and are spectrally limited to the visible range. Here, we present a general strategy to...
  • OER000002689.pdf.jpg
  • Journal article

  • A general, highly efficient and facile synthesis of biocompatible rhodamine dyes and probes for live-cell multicolor nanoscopy

    • Authors : Gerasimaitė, Rūta (2023)

  • The development of live-cell fluorescence nanoscopy is powered by the availability of suitable fluorescent probes. Rhodamines are among the best fluorophores for labeling intracellular structures. Isomeric tuning is a powerful method for optimizing biocompatibility of the rhodamine-containing probes without affecting their spectral properties. However, the efficient synthesis pathway for rhodamine 4-isomers is still lacking. Herein, we present a facile protecting-group-free 4-carboxyrhoda...
  • OER000002427.pdf.jpg
  • Ebooks (Sách điện tử)

  • A TREX1 model reveals double-strand DNA preference and inter-protomer regulation

    • Authors : Hemphill, Wayne O. (2023)

  • The TREX1 3’ à 5’ exonuclease degrades DNA in vivo to prevent chronic immune activation through the cGAS-STING pathway. TREX1 degrades ss- and dsDNA containing a free 3’-hydroxyl, but the precise nature of immune-activating DNA remains an open question. The TREX1 homodimer structure is critical for exonuclease activity with amino acids from one protomer acting across the dimer interface contributing to catalysis in the opposing protomer.&#x...
  • OER000002613.pdf.jpg
  • Journal article

  • Beyond the Active Site: The addition of a remote loop reveals a new complex biological function for chitinase enzymes

    • Authors : Kozome, Dan (2023)

  • Loops are small secondary structural elements that play a crucial role in the emergence of new 14 enzyme functions. However, our understanding of loop functions is mainly limited to the 15 catalytic loops. To understand the function of remote loops in enzymes, we studied Glycoside 16 hydrolase family 19 (GH19) chitinase - an essential enzyme family for pathogen degradation 17 in plants. By revealing the evolutionary history and loops appearance...
  • OER000000337.pdf.jpg
  • Book

  • Bioeconomy: Shaping the Transition to a Sustainable, Biobased Economy

    • Authors : Iris Lewandowski (2018)

  • Part I Bioeconomy Concepts and Research Methods: Bioeconomy Concepts, Inter- and Transdisciplinarity in Bioeconomy. Part II Knowledge Base for Biobased Value Chains: Biobased Resources and Value Chains, Primary Production, Processing of Biobased Resources, Markets, Sustainability Management and Entrepreneurship. Part III Transition to a Sustainable Bioeconomy: Modelling and Tools Supporting the Transition to a Bioeconomy, Environmental Economics, the Bioeconomy and the Role of G...
  • OER000002769.pdf.jpg
  • Journal article

  • Cotranslational folding and assembly of the dimeric E. coli inner membrane protein EmrE

    • Authors : Mermans, Daphne (2023)

  • In recent years, it has become clear that many homo- and heterodimeric cytoplasmic proteins in both prokaryotic and eukaryotic cells start to dimerize cotranslationally, i.e., while at least one of the two chains is still attached to the ribosome. Whether this is possible also for integral membrane proteins is unknown, however. Here, we apply Force Profile Analysis (FPA) – a method where a translational arrest peptide (AP) enginee...
  • OER000002476.pdf.jpg
  • Journal Article

  • Exposing the molecular heterogeneity of glycosylated biotherapeutics

    • Authors : Schachner, Luis F. (2023)

  • Glycosylated biotherapeutics are an emerging class of drugs with high molecular heterogeneity, which can affect their safety and efficacy. Characterizing this heterogeneity is crucial for drug development and quality assessment, but existing methods are limited in their ability to analyze intact glycoproteins. Here, we present a new approach to glycoform fingerprinting that uses proton-transfer charge-reduction with gas-phase fractionation to analyze intact&#...
  • OER000002704.pdf.jpg
  • Journal article

  • Fip1 is a multivalent interaction scaffold for processing factors in human mRNA 3’ end biogenesis

    • Authors : Muckenfuss, Lena M. (2023)

  • 3’ end formation of most eukaryotic mRNAs is dependent on the assembly of a ~1.5 megadalton 3 multiprotein complex, that catalyzes the coupled reaction of pre-mRNA cleavage and polyadenylation. 4 In mammals, the cleavage and polyadenylation specificity factor (CPSF) constitutes the core of the 5 3’ end processing machinery onto which the remaining factors, including cleavage stimulation factor 6 (CstF) and poly(A) polymerase (PAP), assemble....
  • OER000000352.pdf.jpg
  • Book

  • Green, Closed Loop, Circular Bio-Economy

    • Authors : Charisios Achillas; Dionysis Bochtis (2021)

  • In recent years, bioeconomy strategies have been implemented and adapted internationally. In the bioeconomy, materials are to a certain extent circular by nature. However, biomaterials may also be used in a rather linear way. Lately, a transition towards a circular economy, a more restorative and regenerative economic model, is being promoted worldwide. Toward a Green, Closed-Loop, Circular Bioeconomy: Boosting the Performance Efficiency of Circular Business Model...
  • OER000002278.pdf.jpg
  • Ebooks (Sách điện tử)

  • Instructor’s Guide to Concepts of Biology

    • Authors : Smith, Molly; Selby, Sara (2015)

  • This Instructor’s Guide contains the brief outlines of Chapters 12-21 as found in Concepts of Biology, though some underwent revision. Also, instructors will find detailed outlines of the text for use in lecturing, as well as structured outlines that may be used by students to take notes while reading the chapter or during lecture. All outlines are derived from the OpenStax text. Additionally, study guides that contain a vari...