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Ebooks (Sách điện tử)

Differences in the regulation mechanisms of the glutamine synthetase from methanogenic archaea unveiled by structural investigations

Authors : Müller, Marie-Caroline (2023)

Glutamine synthetases catalyze the ATP-dependent ammonium assimilation, the initial step of nitrogen 18 acquisition that must be tightly regulated to fit cellular needs. While their catalytic mechanisms and 19 regulation are well-characterized in bacteria and eukaryotes, only limited knowledge exists about the 20 archaeal representatives. Here, we natively purified the glutamine synthetases type I-α from 21 Methanothermococcus thermolithotrophicus and Methermicoccus shengliensis, two...

Journal article

Molecular mechanism of quorum sensing inhibition in Streptococcus by the phage protein paratox

Authors : Rutbeek, Nicole R. (2021)

Streptococcus pyogenes, or Group A Streptococcus, is a Gram-positive bacterium that 4 can be both a human commensal and pathogen. Central to this dichotomy are temperate 5 bacteriophages that incorporate into the bacterial genome as a prophage. These genetic 6 elements encode both the phage proteins as well as toxins harmful to the human host. 7 One such conserved phage protein paratox (Prx) is always found enco...

Journal Article

Strategy of selection and optimization of single domain antibodies targeting the PHF6 linear peptide within the Tau intrinsically disordered protein

Authors : Mortelecque, Justine (-)

VHHs (Variable Heavy-chain of the Heavy-chain-only antibodies), also named single domain antibodies or nanobodies (1), are the smallest domains of natural Camelidae single chain antibodies that are still capable to recognize an antigen. Their many interesting properties and potential for engineering make VHHs ideal candidates for the design of innovative treatments (2) and new investigation tools (3, 4), including for in-cell imaging (5). Their ...