Ebooks (Sách điện tử)Authors : Hemphill, Wayne O. (2023)
The TREX1 3’ à 5’ exonuclease degrades DNA in vivo to prevent chronic immune activation through
the cGAS-STING pathway. TREX1 degrades ss- and dsDNA containing a free 3’-hydroxyl, but the precise
nature of immune-activating DNA remains an open question. The TREX1 homodimer structure is critical for
exonuclease activity with amino acids from one protomer acting across the dimer interface contributing to
catalysis in the opposing protomer.&#x... 
