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Showing results 1 to 3 of 3

Journal article

Biophysical characterization and analysis of a mesophilic chorismate mutase from B. pumilus

Authors : Wilkins, Ryan Scott (2023)

Chorismate mutases have extensively been used as computational benchmarking systems for enzyme catalysis, yet the roles entropy and enthalpy play in catalysis are still not fully understood. Thus, it is important to better understand these enzymes for potential research or industrial applications. Here, we report the first crystal structure and kinetic characterization of a chorismate mutase from Bacillus pumilus. This enzyme exhibits a high degree of similar...

Journal article

Diverse Phosphoserine Phosphatases Exhibit Maximum Activity at an Intermediate Binding Affinity in Accord with the Sabatier Principle of Catalysis

Authors : Chiba, Yoko (2023)

A unified framework to rationalize enzymatic activity is essential to understand cellular function and metabolic evolution. Recent studies have shown that the activity of several hydrolases is maximized when the substrate binding affinity (Michaelis-Menten constant:) is neither too strong nor too weak. This is because an intermediate resolves the trade-off between, in accord with the Sabatier principle of artificial catalysis. However, it remains unc...

Journal Article

Structural properties of the HNF-1A transactivation domain

Authors : Kind, Laura (2023)

Hepatocyte nuclear factor 1α (HNF-1A) is a transcription factor with important gene regulatory roles in pancreatic β-cells. HNF1A gene variants are associated with a monogenic form of diabetes (HNF1A-MODY) or an increased risk for type 2 diabetes. While several pancreatic target genes of HNF-1A have been described, a lack of knowledge regarding the structure-function relationships in HNF-1A prohibits a detailed understanding of HNF-1A-mediated gene transcription, ...