- Journal article
Tác giả : Gupta, Pooja (2021) - The L-arginine biosynthesis pathway consists of eight enzymes that catalyse the conversion of L- glutamate to L-arginine, appears to be attractive target for anti-Tuberculosis (TB) drug discovery. Starvation of M. tuberculosis deleted for either argB or argF genes led to rapid sterilization of these strains in mice while Chemical inhibition of ArgJ with Pranlukast was also found to clear chronic M. tuberculosis infection in animal models. In this wo...
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- Journal Article
Tác giả : Crispim, Marcell (2023) - Plasmodium falciparum causes the most severe form of human malaria, a parasitic disease with a high global burden. In 2021, the World Health Organization reported an estimated 247 million cases of malaria and 619,000 malaria-related deaths, with the majority occurring among children and pregnant women in Sub-Saharan Africa. In 2021, 96% of all malaria-related deaths occurred in this region. Resistance to current antimalarial drugs is a signi...
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- Ebooks (Sách điện tử)
Tác giả : Tiwari, Satish (2023) - To overcome the drug resistance crisis and shorten the current duration of human tuberculosis (TB) therapy, new anti-TB molecules is required. In an earlier study, we have shown that Mycobacterium tuberculosis (Mtb), the causative agent of TB, with a fractured de novo histidine biosynthesis fails to mount TB infection in mouse model, emboldening that disrupting the function of this pathway may constitute a novel strategy to curtailing TB infection.&...
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- Journal article
Tác giả : Gruzdev, Nadya (2023) - Methionine is an essential amino acid in mammals and a critical metabolite in all
organisms. As such, various applications, including food, feed, and pharmaceuticals,
necessitate the addition of L-methionine. Although amino acids and other
metabolites are commonly produced through bacterial fermentation, high-yield
biosynthesis of L-methionine remains a significant challenge due to the strict cellular
regulation of the biosynthesis pathway. As a result,&...
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- Journal article
Tác giả : Ishibashi, JR (2021) - The hexosamine biosynthetic pathway (HBP) produces the essential metabolite UDP-GlcNAc and plays a key role in metabolism, cancer, and aging. The HBP is controlled by its rate-limiting enzyme glutamine fructose-6-phosphate amidotransferase (GFAT) that is directly inhibited by UDP-GlcNAc in a feedback loop. HBP regulation by GFAT is well studied but other HBP regulators have remained obscure. Elevated UDP-GlcNAc levels counteract the glycosylation toxin&#x...
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- Journal article
Tác giả : Ruther, Joachim (2021) - Fatty acids are crucial primary metabolites for virtually any creature on earth. Therefore, most organisms do not rely exclusively on nutritional supply with fatty acids but have the ability to synthesize fatty acids and triacylglycerides de novo from carbohydrates, a process called lipogenesis. The ubiquity of lipogenesis has been questioned by a series of studies reporting that many parasitic wasps (parasitoids) do not accumulate lipid mass despite hav...
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- Journal Article
Tác giả : McElroy, Craig (2023) - Cellular production of tryptophan is metabolically expensive and tightly regulated. The small
Bacillus subtilis zinc binding Anti-TRAP protein (AT), which is the product of the yczA/rtpA
gene, is upregulated in response to accumulating levels of uncharged tRNATrp through a T-box
antitermination mechanism. AT binds to the undecameric ring-shaped protein TRAP (trp RNA
Binding Attenuation Protein), thereby preventing it from binding to the trp lead...
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- Journal article
Tác giả : Vuksanovic, Nemanja (2023) - MppQ is an enzyme of unknown function from Streptomyces hygroscopicus that is involved in the biosynthesis of the nonproteinogenic amino acid L-enduracididine (L-End). Since L-End is a component of several peptides showing high activity against methicillin-resistant Staphylococcus aureus (MRSA), a complete understanding of its biosynthetic pathway is of utmost importance for developing chemoenzymatic routes for syntheses of novel antibiotics. In this work, we report hi...
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- Journal Article
Tác giả : Ngo, Thuan-Ethan (2023) - The tropical marine cyanobacterium Moorena producens JHB is a prolific source of secondary metabolites with
potential biomedical utility. Previous studies of this strain led to the discovery of several novel compounds such as the hectochlorins
and jamaicamides; however, bioinformatic analyses of its genome suggested that there were many more cryptic biosynthetic gene
clusters yet to be characterized. To potentially stimulate the production of novel co...
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- Journal article
Tác giả : Soares da Costa, Tatiana P. (2021) - Weeds are becoming increasingly resistant to our current herbicides, posing a significant threat to agricultural production. Therefore, new herbicides are urgently needed. In this study, we exploited a novel herbicide target, dihydrodipicolinate synthase (DHDPS), which catalyses the first and rate-limiting step in lysine biosynthesis. Using a high throughput chemical screen, we identified the first class of plant DHDPS inhibitors that have micromolar potency against Ar...
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