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Industry article

Characterisation of the SUF FeS cluster machinery in the amitochondriate eukaryote Monocercomonoides exilis

Authors : Diaz, Priscila Peña (2023)

Monocercomonoides exilis is the first eukaryotic organism described as a complete amitochondriate,24 yet it shares common features with heterotrophic anaerobic/microaerophilic protists, some of which25 bear divergent mitochondrion-related organelles or MROs. It has been postulated that the retention26 of these organelles stems from their involvement in the assembly of essential cytosolic and nuclear27 FeS proteins, whose maturation requires the evolutionarily conse...

Journal article

Differential Expression of Gluconeogenesis-Related Transcripts in a Freshwater Zooplankton Model Organism Suggests a Role of the Cori Cycle in Hypoxia Tolerance

Authors : Malek, M. C. (2023)

Gluconeogenesis (GNG) is the process of regenerating glucose and NAD+ that allows continuing ATP 31 synthesis by glycolysis during fasting or in hypoxia. Recent data from C. elegans and crustaceans 32 challenged with hypoxia show differential and tissue-specific expression of GNG-specific genes. 33 2. Here we report differential expression of several GNG-specific genes in the head and body of a model 34 organism, Daphnia magna, a plank...

Journal article

Histone sequence variation in divergent eukaryotes facilitates diversity in chromatin packaging

Authors : Patwal, Indu (2021)

The histone proteins defining nucleosome structure are highly conserved in common model organisms and are frequently portrayed as uniform chromatin building blocks. We surveyed over 1700 complete eukaryotic genomes and confirm that almost all encode recognisable canonical core histones. Nevertheless, divergent eukaryotes show unrecognised diversity in histone sequences and offer an opportunity to observe the potential for nucleosome variation. Recombinant his...