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Journal article

Mechanism of GTPase activation of a prokaryotic small Ras-like GTPase MglA by an asymmetrically interacting MglB dimer

Authors : Chakraborty, Sukanya (2023)

Cell polarity oscillations in Myxococcus xanthus motility are driven by a prokaryotic 23 small Ras-like GTPase, MglA, which switches from one cell pole to the other in 24 response to extracellular signals. MglA dynamics is regulated by MglB, which 25 functions both as a GAP (GTPase activating protein) and a GEF (guanine nucleotide 26 exchange factor) for MglA. With an aim to dissect the role of asymmetry in the dual ...

Journal article

Production of a functionally active recombinant SARS-CoV-2 (COVID-19) 3C-Like protease and a soluble inactive 3C-like protease-RBD chimeric in a prokaryotic expression system

Authors : Verissimo, Carolina De Marco (2023)

During the SARS-CoV-2 intracellular life-cycle, two large polyproteins, pp1a and pp1ab, are 29 produced. Processing of these by viral cysteine proteases, the papain-like protease (PLpro) and 30 the chymotrypsin-like 3C-like protease (3CL-pro) release non-structural proteins necessary for 31 the establishment of the viral replication and transcription complex (RTC), crucial for viral 32 replication. Hence, these proteases are considered prime targets against which anti-COVID-19&#...

Journal article

Structure and mechanistic features of the prokaryotic minimal RNase P

Authors : Feyh, Rebecca (2021)

Endonucleolytic removal of 5’-leader sequences from tRNA precursor transcripts (pre-tRNAs) by RNase P is essential for protein synthesis. Beyond RNA-based RNase P enzymes, protein-only versions of the enzyme exert this function in various Eukarya (there termed PRORPs) and in some bacteria (Aquifex aeolicus and close relatives); both enzyme types belong to distinct subgroups of the PIN domain metallonuclease superfamily. Homologs of Aquifex RNase P (HARPs) are ...